Critical role of reactive oxygen species (ROS) for synergistic enhancement of apoptosis by vemurafenib and the potassium channel inhibitor TRAM-34 in melanoma cells

Inhibition of MAP kinase pathways by selective BRAF inhibitors, such as vemurafenib and dabrafenib, have evolved as key therapies of BRAF-mutated melanoma. However, tumor relapse and therapy resistance have remained as major problems, which may be addressed by combination with other pathway inhibito...

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Detalles Bibliográficos
Autores principales: Bauer, Daniel, Werth, Felix, Nguyen, Ha An, Kiecker, Felix, Eberle, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386497/
https://www.ncbi.nlm.nih.gov/pubmed/28151482
http://dx.doi.org/10.1038/cddis.2017.6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386497/
https://www.ncbi.nlm.nih.gov/pubmed/28151482
http://dx.doi.org/10.1038/cddis.2017.6

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