BH3 mimetic-elicited Ca(2+) signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca(2+)-like peptides

BH3 mimetics are small-molecule inhibitors of B-cell lymphoma-2 (Bcl-2) and Bcl-xL, which disrupt the heterodimerisation of anti- and pro-apoptotic Bcl-2 family members sensitising cells to apoptotic death. These compounds have been developed as anti-cancer agents to counteract increased levels of B...

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Detalles Bibliográficos
Autores principales: Ferdek, Pawel E, Jakubowska, Monika A, Nicolaou, Polina, Gerasimenko, Julia V, Gerasimenko, Oleg V, Petersen, Ole H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386550/
https://www.ncbi.nlm.nih.gov/pubmed/28252652
http://dx.doi.org/10.1038/cddis.2017.41

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386550/
https://www.ncbi.nlm.nih.gov/pubmed/28252652
http://dx.doi.org/10.1038/cddis.2017.41

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