Epidermal Rac1 regulates the DNA damage response and protects from UV-light-induced keratinocyte apoptosis and skin carcinogenesis

Non-melanoma skin cancer (NMSC) is the most common type of cancer. Increased expression and activity of Rac1, a small Rho GTPase, has been shown previously in NMSC and other human cancers; suggesting that Rac1 may function as an oncogene in skin. DMBA/TPA skin carcinogenesis studies in mice have sho...

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Detalles Bibliográficos
Autores principales: Deshmukh, Jayesh, Pofahl, Ruth, Haase, Ingo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386559/
https://www.ncbi.nlm.nih.gov/pubmed/28277539
http://dx.doi.org/10.1038/cddis.2017.63

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386559/
https://www.ncbi.nlm.nih.gov/pubmed/28277539
http://dx.doi.org/10.1038/cddis.2017.63

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