Hyaluronan activates Hyal-2/WWOX/Smad4 signaling and causes bubbling cell death when the signaling complex is overexpressed

Malignant cancer cells frequently secrete significant amounts of transforming growth factor beta (TGF-β), hyaluronan (HA) and hyaluronidases to facilitate metastasizing to target organs. In a non-canonical signaling, TGF-β binds membrane hyaluronidase Hyal-2 for recruiting tumor suppressors WWOX and...

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Detalles Bibliográficos
Autores principales: Hsu, Li-Jin, Hong, Qunying, Chen, Shur-Tzu, Kuo, Hsiang-Lin, Schultz, Lori, Heath, John, Lin, Sing-Ru, Lee, Ming-Hui, Li, Dong-Zhang, Li, Zih-Ling, Cheng, Hui-Ching, Armand, Gerard, Chang, Nan-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386674/
https://www.ncbi.nlm.nih.gov/pubmed/27845895
http://dx.doi.org/10.18632/oncotarget.13268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386674/
https://www.ncbi.nlm.nih.gov/pubmed/27845895
http://dx.doi.org/10.18632/oncotarget.13268

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