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Hyaluronan activates Hyal-2/WWOX/Smad4 signaling and causes bubbling cell death when the signaling complex is overexpressed
Malignant cancer cells frequently secrete significant amounts of transforming growth factor beta (TGF-β), hyaluronan (HA) and hyaluronidases to facilitate metastasizing to target organs. In a non-canonical signaling, TGF-β binds membrane hyaluronidase Hyal-2 for recruiting tumor suppressors WWOX and...
Autores principales: | Hsu, Li-Jin, Hong, Qunying, Chen, Shur-Tzu, Kuo, Hsiang-Lin, Schultz, Lori, Heath, John, Lin, Sing-Ru, Lee, Ming-Hui, Li, Dong-Zhang, Li, Zih-Ling, Cheng, Hui-Ching, Armand, Gerard, Chang, Nan-Shan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386674/ https://www.ncbi.nlm.nih.gov/pubmed/27845895 http://dx.doi.org/10.18632/oncotarget.13268 |
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