Secreted GRP78 activates EGFR-SRC-STAT3 signaling and confers the resistance to sorafeinib in HCC cells

Acquired resistance is a common phenomenon for HCC patients who undergone sorafenib treatment, however the mechanism by which acquired resistance develops remains elusive. In this study, we found that GRP78 could be detected in the serum samples of HCC patients and the conditional medium of multiple...

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Detalles Bibliográficos
Autores principales: Li, Rui, Yanjiao, Gu, Wubin, He, Yue, Wang, Jianhua, Huang, Huachuan, Zheng, Rongjian, Su, Zhidong, Luan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386689/
https://www.ncbi.nlm.nih.gov/pubmed/28423613
http://dx.doi.org/10.18632/oncotarget.15223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386689/
https://www.ncbi.nlm.nih.gov/pubmed/28423613
http://dx.doi.org/10.18632/oncotarget.15223

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