Ochratoxin A induces ER stress and apoptosis in mesangial cells via a NADPH oxidase-derived reactive oxygen species-mediated calpain activation pathway

Ochratoxin A (OTA) contaminated food increases reactive oxygen species (ROS) production in glomerulus and causes glomerulopathy. The molecular mechanisms still remain uncertain. In this study, we used mouse and rat glomerular mesangial cells and delineate the signaling pathway behind the OTA-trigger...

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Detalles Bibliográficos
Autores principales: Sheu, Meei-Ling, Shen, Chin-Chang, Chen, Yuan-Siao, Chiang, Chih-Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386691/
https://www.ncbi.nlm.nih.gov/pubmed/28038445
http://dx.doi.org/10.18632/oncotarget.14270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386691/
https://www.ncbi.nlm.nih.gov/pubmed/28038445
http://dx.doi.org/10.18632/oncotarget.14270

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