Overexpression of pregnane X and glucocorticoid receptors and the regulation of cytochrome P450 in human epileptic brain endothelial cells

OBJECTIVE: Recent evidence suggests a metabolic contribution of cytochrome P450 enzymes (CYPs) to the drug‐resistant phenotype in human epilepsy. However, the upstream molecular regulators of CYP in the epileptic brain remain understudied. We therefore investigated the expression and function of pre...

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Detalles Bibliográficos
Autores principales: Ghosh, Chaitali, Hossain, Mohammed, Solanki, Jesal, Najm, Imad M., Marchi, Nicola, Janigro, Damir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Full‐length Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386820/
https://www.ncbi.nlm.nih.gov/pubmed/28199000
http://dx.doi.org/10.1111/epi.13703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386820/
https://www.ncbi.nlm.nih.gov/pubmed/28199000
http://dx.doi.org/10.1111/epi.13703

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