Cargando…

Overexpression of pregnane X and glucocorticoid receptors and the regulation of cytochrome P450 in human epileptic brain endothelial cells

OBJECTIVE: Recent evidence suggests a metabolic contribution of cytochrome P450 enzymes (CYPs) to the drug‐resistant phenotype in human epilepsy. However, the upstream molecular regulators of CYP in the epileptic brain remain understudied. We therefore investigated the expression and function of pre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ghosh, Chaitali, Hossain, Mohammed, Solanki, Jesal, Najm, Imad M., Marchi, Nicola, Janigro, Damir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Full‐length Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386820/ https://www.ncbi.nlm.nih.gov/pubmed/28199000 http://dx.doi.org/10.1111/epi.13703

Ejemplares similares

Modulation of glucocorticoid receptor in human epileptic endothelial cells impacts drug biotransformation in an in vitro blood–brain barrier model
por: Ghosh, Chaitali, et al.
Publicado: (2018)

Cytochrome P450-mediated antiseizure medication interactions influence apoptosis, modulate the brain BAX/Bcl-X(L) ratio and aggravate mitochondrial stressors in human pharmacoresistant epilepsy
por: Ghosh, Chaitali, et al.
Publicado: (2022)

Expression and Functional Relevance of Death-Associated Protein Kinase in Human Drug-Resistant Epileptic Brain: Focusing on the Neurovascular Interface
por: Williams, Sherice, et al.
Publicado: (2018)

Mathematical Models in the Description of Pregnane X Receptor (PXR)-Regulated Cytochrome P450 Enzyme Induction
por: Duintjer Tebbens, Jurjen, et al.
Publicado: (2018)

Modulation of Cytochrome P450, P-glycoprotein and Pregnane X Receptor by Selected Antimalarial Herbs—Implication for Herb-Drug Interaction
por: Fasinu, Pius S., et al.
Publicado: (2017)

The utility of an automated and ambulatory device for detecting and differentiating epileptic and psychogenic non‐epileptic seizures
por: Naganur, Vaidehi D., et al.
Publicado: (2019)

Glucocorticoid Receptor β Isoform Predominates in the Human Dysplastic Brain Region and Is Modulated by Age, Sex, and Antiseizure Medication
por: Westcott, Rosemary, et al.
Publicado: (2022)

Overtightening of halo pins resulting in intracranial penetration, pneumocephalus, and epileptic seizure
por: Glover, Alexander W., et al.
Publicado: (2013)

LncRNAs AK058003 and MVIH Overexpression in the Blood Samples of Iranian Breast Cancer Patients
por: Akhavan Attar, Fatemeh, et al.
Publicado: (2021)

Coexistence of bone and vascular disturbances in patients with endogenous glucocorticoid excess
por: Yano, Chieko, et al.
Publicado: (2022)

The role of shear stress in Blood-Brain Barrier endothelial physiology
por: Cucullo, Luca, et al.
Publicado: (2011)

PLPBP mutations cause variable phenotypes of developmental and epileptic encephalopathy
por: Shiraku, Hiroshi, et al.
Publicado: (2018)

Semiology of spontaneous generalized tonic‐clonic seizures in the epileptic baboon
por: Szabó, Charles Ákos, et al.
Publicado: (2020)

Slow oscillations open susceptible time windows for epileptic discharges
por: Sheybani, Laurent, et al.
Publicado: (2021)

Significance of MDR1 and multiple drug resistance in refractory human epileptic brain
por: Marchi, Nicola, et al.
Publicado: (2004)

Interactive Effects of Glucocorticoids and Cytochrome P450 Polymorphisms on the Plasma Trough Concentrations of Voriconazole
por: Jia, Su-jie, et al.
Publicado: (2021)

Time to push the age limit: Epilepsy surgery in patients 60 years or older
por: Punia, Vineet, et al.
Publicado: (2018)

Detection of brain-directed autoantibodies in the serum of non-small cell lung cancer patients
por: Banjara, Manoj, et al.
Publicado: (2017)

Gene panel analysis for nonsyndromic cryptogenic neonatal/infantile epileptic encephalopathy
por: Fung, Cheuk‐Wing, et al.
Publicado: (2017)

Developmental and epileptic encephalopathy: Personal utility of a genetic diagnosis for families
por: Jeffrey, Jennifer S., et al.
Publicado: (2021)

Efficacy of Anti-Inflammatory Therapy in a Model of Acute Seizures and in a Population of Pediatric Drug Resistant Epileptics
por: Marchi, Nicola, et al.
Publicado: (2011)

Molecular effects and retinopathy induced by hydroxychloroquine during SARS-CoV-2 therapy: Role of CYP450 isoforms and epigenetic modulations
por: Paniri, Alireza, et al.
Publicado: (2020)

A Modified Arrhenius Approach to Thermodynamically Study Regioselectivity in Cytochrome P450‐Catalyzed Substrate Conversion
por: Luirink, Rosa A., et al.
Publicado: (2020)

Artesunate protects immunosuppression mice induced by glucocorticoids via enhancing pro-inflammatory cytokines release and bacterial clearance
por: Wang, Yan, et al.
Publicado: (2021)

Consequences of Repeated Blood-Brain Barrier Disruption in Football Players
por: Marchi, Nicola, et al.
Publicado: (2013)

Overexpression of TGN38/41 leads to mislocalisation of γ‐adaptin
por: Reaves, Barbara, et al.
Publicado: (1994)

Mitral valve replacement for mitral stenosis: A 15-year single center experience
por: Al Mosa, Alqasem F., et al.
Publicado: (2016)

EEG desynchronization during phasic REM sleep suppresses interictal epileptic activity in humans
por: Frauscher, Birgit, et al.
Publicado: (2016)

Role of intraoperative transesophageal echocardiography in pediatric cardiac surgery
por: Jijeh, Abdulraouf M.Z., et al.
Publicado: (2016)

Lignin Biodegradation by a Cytochrome P450 Enzyme: A Computational Study into Syringol Activation by GcoA
por: Ali, Hafiz Saqib, et al.
Publicado: (2020)

The phenotypic spectrum of X‐linked, infantile onset ALG13‐related developmental and epileptic encephalopathy
por: Datta, Alexandre N., et al.
Publicado: (2021)

Prolonged epileptic discharges predict seizure recurrence in JME: Insights from prolonged ambulatory EEG
por: Turco, Francesco, et al.
Publicado: (2021)

Motion and Flexibility in Human Cytochrome P450 Aromatase
por: Jiang, Wenhua, et al.
Publicado: (2012)

Is Peripheral Immunity Regulated by Blood-Brain Barrier Permeability Changes?
por: Bargerstock, Erin, et al.
Publicado: (2014)

L-Type calcium channel blockade reduces network activity in human epileptic hypothalamic hamartoma tissue
por: Simeone, Kristina A, et al.
Publicado: (2011)

Increased gamma and decreased fast ripple connections of epileptic tissue: A high‐frequency directed network approach
por: Zweiphenning, Willemiek J. E. M., et al.
Publicado: (2019)

Triterpene Structural Diversification by Plant Cytochrome P450 Enzymes
por: Ghosh, Sumit
Publicado: (2017)

The Cytochrome P450 Homepage
por: Nelson, David R
Publicado: (2009)

Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450
por: Campelo, Diana, et al.
Publicado: (2018)

A knock‐in mouse model for KCNQ2‐related epileptic encephalopathy displays spontaneous generalized seizures and cognitive impairment
por: Milh, Mathieu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_6l5a9rj4rt1ob3lsa7nb9vb3nk