Mechanistic Validation of a Clinical Lead Stapled Peptide that Reactivates p53 by Dual HDM2 and HDMX Targeting

Hydrocarbon-stapled peptides that display key residues of the p53 transactivation domain have emerged as bona fide clinical candidates for reactivating the tumor suppression function of p53 in cancer by dual targeting of the negative regulators HDM2 and HDMX. A recent study questioned the mechanisti...

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Detalles Bibliográficos
Autores principales: Wachter, Franziska, Morgan, Ann M., Godes, Marina, Mourtada, Rida, Bird, Gregory H., Walensky, Loren D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386833/
https://www.ncbi.nlm.nih.gov/pubmed/27721413
http://dx.doi.org/10.1038/onc.2016.361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386833/
https://www.ncbi.nlm.nih.gov/pubmed/27721413
http://dx.doi.org/10.1038/onc.2016.361

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