Cargando…

Mechanistic Validation of a Clinical Lead Stapled Peptide that Reactivates p53 by Dual HDM2 and HDMX Targeting

Hydrocarbon-stapled peptides that display key residues of the p53 transactivation domain have emerged as bona fide clinical candidates for reactivating the tumor suppression function of p53 in cancer by dual targeting of the negative regulators HDM2 and HDMX. A recent study questioned the mechanisti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wachter, Franziska, Morgan, Ann M., Godes, Marina, Mourtada, Rida, Bird, Gregory H., Walensky, Loren D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386833/ https://www.ncbi.nlm.nih.gov/pubmed/27721413 http://dx.doi.org/10.1038/onc.2016.361

Ejemplares similares

Alterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53
por: Heminger, Katherine, et al.
Publicado: (2009)

Understanding the interaction of 14‐3‐3 proteins with hDMX and hDM2: a structural and biophysical study
por: Srdanović, Sonja, et al.
Publicado: (2022)

Biophysical Determinants for Cellular Uptake of Hydrocarbon-Stapled Peptide Helices
por: Bird, Gregory H., et al.
Publicado: (2016)

Design of Stapled Antimicrobial Peptides that Overcome Antibiotic Resistance and In Vivo Toxicity
por: Mourtada, Rida, et al.
Publicado: (2019)

Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress: Miniperspective
por: Walensky, Loren D., et al.
Publicado: (2014)

Effect of linker on the binding free energy of stapled p53/HDM2 complex
por: Im, Haeri, et al.
Publicado: (2020)

Inhibition of Nutlin-Resistant HDM2 Mutants by Stapled Peptides
por: Wei, Siau Jia, et al.
Publicado: (2013)

Cryptic in vitro ubiquitin ligase activity of HDMX towards p53 is probably regulated by an induced fit mechanism
por: Calderon-González, Karla Gisel, et al.
Publicado: (2022)

Stapled HIV-1 Peptides Recapitulate Antigenic Structures and Engage Broadly Neutralizing Antibodies
por: Bird, Gregory H., et al.
Publicado: (2014)

5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2()
por: Dickens, Michael P., et al.
Publicado: (2013)

Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity, proteolytic stability and cell uptake
por: de Araujo, Aline D., et al.
Publicado: (2022)

Inhibition of FOXP3 by stapled alpha-helical peptides dampens regulatory T cell function
por: Hawley, Katrina M., et al.
Publicado: (2022)

The Expression and Function of NUMB in Endometrial Cancer and the Interaction with HDM2 and P53
por: Wang, Chao, et al.
Publicado: (2015)

Oligobenzamide proteomimetic inhibitors of the p53–hDM2 protein–protein interaction
por: Plante, Jeffrey P., et al.
Publicado: (2009)

Searches for 2HDM at the LHC
por: Chakraborty, Dhiman
Publicado: (2014)

HDM2 ERKs PCNA
por: Nguyen, Hai Dang, et al.
Publicado: (2010)

Searches for 2HDM at the LHC
por: Koehlmann, S
Publicado: (2013)

A single nucleotide polymorphism in the HDM-2 gene regulates the p53 apoptotic response and influences the age of onset of cancers in humans: the SNP 309 HDM-2 polymorphism
por: Bond, GL, et al.
Publicado: (2005)

Peptide, Peptidomimetic, and Small-molecule Antagonists of the p53–HDM2 Protein–Protein Interaction
por: Fischer, Peter M.
Publicado: (2006)

Negative regulation of HDM2 to attenuate p53 degradation by ribosomal protein L26
por: Zhang, Ying, et al.
Publicado: (2010)

Activity‐Directed Synthesis of Inhibitors of the p53/hDM2 Protein–Protein Interaction
por: Green, Adam I., et al.
Publicado: (2020)

Allosteric changes in HDM2 by the ATM phosphomimetic S395D mutation: implications on HDM2 function
por: Uhrik, Lukas, et al.
Publicado: (2019)

Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress
por: Bai, Dongmei, et al.
Publicado: (2014)

Helicobacter pylori bacteria alter the p53 stress response via Erk-HDM2 pathway
por: Bhardwaj, Vikas, et al.
Publicado: (2015)

TP53 mutations emerge with HDM2 inhibitor SAR405838 treatment in de-differentiated liposarcoma
por: Jung, Joonil, et al.
Publicado: (2016)

Inhibition of the p53/hDM2 protein-protein interaction by cyclometallated iridium(III) compounds
por: Liu, Li-Juan, et al.
Publicado: (2016)

On the mass and the matter state of the HDM neutrinos
por: Huang Wu Liang
Publicado: (1994)

Exotic or 2HDM Higgs at LEP
por: Kiiskinen, A P
Publicado: (2001)

Higgs EFT for 2HDM and beyond
por: Bélusca-Maïto, Hermès, et al.
Publicado: (2017)

HDM2 antagonist MI-219 (spiro-oxindole), but not Nutlin-3 (cis-imidazoline), regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant B-cell lymphomas
por: Sosin, Angela M, et al.
Publicado: (2012)

Role of p14ARF-HDM2-p53 axis in SOX6-mediated tumor suppression
por: Wang, J, et al.
Publicado: (2016)

Characterization and Molecular Mechanism of Peptide-Conjugated Gold Nanoparticle Inhibiting p53-HDM2 Interaction in Retinoblastoma
por: Kalmodia, Sushma, et al.
Publicado: (2017)

A distinct p53 target gene set predicts for response to the selective p53–HDM2 inhibitor NVP-CGM097
por: Jeay, Sébastien, et al.
Publicado: (2015)

PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis
por: Sarafraz-Yazdi, Ehsan, et al.
Publicado: (2022)

2HDM-based and SUSY-inspired models
por: Cortes-Gonzalez, Arely
Publicado: (2018)

A Spiroligomer α-Helix Mimic That Binds HDM2, Penetrates Human Cells and Stabilizes HDM2 in Cell Culture
por: Brown, Zachary Z., et al.
Publicado: (2012)

Correction: A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097
por: Jeay, Sébastien, et al.
Publicado: (2016)

p14(ARF )expression in invasive breast cancers and ductal carcinoma in situ – relationships to p53 and Hdm2
por: Vestey, SB, et al.
Publicado: (2004)

p14ARF induces the relocation of HDM2 and p53 to extranucleolar sites that are targeted by PML bodies and proteasomes
por: Kashuba, Elena, et al.
Publicado: (2003)

Hdm2 is an Ubiquitin Ligase of Ku70 -Akt Promotes Cell Survival by Inhibiting Hdm2-dependent Ku70 Destabilization
por: Gama, Vivian, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_avlgb08g877mfklk8a0mkub2sv