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Human Cell Assays for Synthesis-Dependent Strand Annealing and Crossing over During Double-Strand Break Repair

DNA double-strand breaks (DSBs) are one of the most deleterious types of lesions to the genome. Synthesis-dependent strand annealing (SDSA) is thought to be a major pathway of DSB repair, but direct tests of this model have only been conducted in budding yeast and Drosophila. To better understand th...

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Detalles Bibliográficos
Autores principales: Zapotoczny, Grzegorz, Sekelsky, Jeff
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386867/
https://www.ncbi.nlm.nih.gov/pubmed/28179392
http://dx.doi.org/10.1534/g3.116.037390