Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling

De novo mutations in CHD8 are strongly associated with autism spectrum disorder (ASD), however the basic biology of CHD8 remains poor understood. Here we report that Chd8 knockdown during cortical development results in defective neural progenitor proliferation and differentiation that ultimately ma...

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Detalles Bibliográficos
Autores principales: Durak, Omer, Gao, Fan, Kaeser-Woo, Yea Jin, Rueda, Richard, Martorell, Anthony J., Nott, Alexi, Liu, Carol Y., Watson, L. Ashley, Tsai, Li-Huei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386887/
https://www.ncbi.nlm.nih.gov/pubmed/27694995
http://dx.doi.org/10.1038/nn.4400

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386887/
https://www.ncbi.nlm.nih.gov/pubmed/27694995
http://dx.doi.org/10.1038/nn.4400

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