Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells

Aberrant signaling transduction induced by mutant KRAS proteins occurs in 20∼30% of non-small cell lung cancer (NSCLC), however, a direct and effective pharmacological inhibitor targeting KRAS has not yet reached the clinic to date. Honokiol, a small molecular polyphenol natural biophenolic compound...

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Detalles Bibliográficos
Autores principales: Luo, Lian-Xiang, Li, Ying, Liu, Zhong-Qiu, Fan, Xing-Xing, Duan, Fu-Gang, Li, Run-Ze, Yao, Xiao-Jun, Leung, Elaine Lai-Han, Liu, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387050/
https://www.ncbi.nlm.nih.gov/pubmed/28443025
http://dx.doi.org/10.3389/fphar.2017.00199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387050/
https://www.ncbi.nlm.nih.gov/pubmed/28443025
http://dx.doi.org/10.3389/fphar.2017.00199

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