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Improved Model of Proton Pump Crystal Structure Obtained by Interactive Molecular Dynamics Flexible Fitting Expands the Mechanistic Model for Proton Translocation in P-Type ATPases

The plasma membrane H(+)-ATPase is a proton pump of the P-type ATPase family and essential in plants and fungi. It extrudes protons to regulate pH and maintains a strong proton-motive force that energizes e.g., secondary uptake of nutrients. The only crystal structure of a H(+)-ATPase (AHA2 from Ara...

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Detalles Bibliográficos
Autores principales: Focht, Dorota, Croll, Tristan I., Pedersen, Bjorn P., Nissen, Poul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387105/
https://www.ncbi.nlm.nih.gov/pubmed/28443028
http://dx.doi.org/10.3389/fphys.2017.00202