Dasatinib inhibits actin fiber reorganization and promotes endothelial cell permeability through RhoA‐ROCK pathway

Treatment with dasatinib, a tyrosine kinase inhibitor, is associated with edema, pleural effusion, and pulmonary edema. We investigated the effect of dasatinib on the barrier function of human microvascular endothelial cells‐1 (HMEC‐1) in vitro and in vivo. The permeability of HMEC‐1 to fluorescein...

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Detalles Bibliográficos
Autores principales: Dasgupta, Swapan K., Le, Anhquyen, Vijayan, K. Vinod, Thiagarajan, Perumal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387130/
https://www.ncbi.nlm.nih.gov/pubmed/28316141
http://dx.doi.org/10.1002/cam4.1019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387130/
https://www.ncbi.nlm.nih.gov/pubmed/28316141
http://dx.doi.org/10.1002/cam4.1019

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