Functional and structural studies on the Neisseria gonorrhoeae GmhA, the first enzyme in the glycero‐manno‐heptose biosynthesis pathways, demonstrate a critical role in lipooligosaccharide synthesis and gonococcal viability

Sedoheptulose‐7‐phosphate isomerase, GmhA, is the first enzyme in the biosynthesis of nucleotide‐activated‐glycero‐manno‐heptoses and an attractive, yet underexploited, target for development of broad‐spectrum antibiotics. We demonstrated that GmhA homologs in Neisseria gonorrhoeae and N. meningitid...

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Detalles Bibliográficos
Autores principales: Wierzbicki, Igor H., Zielke, Ryszard A., Korotkov, Konstantin V., Sikora, Aleksandra E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387315/
https://www.ncbi.nlm.nih.gov/pubmed/28063198
http://dx.doi.org/10.1002/mbo3.432

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387315/
https://www.ncbi.nlm.nih.gov/pubmed/28063198
http://dx.doi.org/10.1002/mbo3.432

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