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Citrate shows protective effects on cardiovascular and renal function in ischemia-induced acute kidney injury

BACKGROUND: Ischemia and reperfusion (I/R) is one of the major causes of acute kidney injury (AKI). Citrate reduces hypoxia-induced mitochondrial energetic deficits in isolated proximal tubules. Moreover, citrate anticoagulation is now frequently used in renal replacement therapy. In the present stu...

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Detalles Bibliográficos
Autores principales: Bienholz, Anja, Reis, Jonas, Sanli, Pinar, de Groot, Herbert, Petrat, Frank, Guberina, Hana, Wilde, Benjamin, Witzke, Oliver, Saner, Fuat H., Kribben, Andreas, Weinberg, Joel M., Feldkamp, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387390/
https://www.ncbi.nlm.nih.gov/pubmed/28395656
http://dx.doi.org/10.1186/s12882-017-0546-1