Glycoengineering of pertuzumab and its impact on the pharmacokinetic/pharmacodynamic properties

Pertuzumab is an antihuman HER2 antibody developed for HER2 positive breast cancer. Glycosylation profiles are always the important issue for antibody based therapy. Previous findings have suggested the impact of glycosylation profiles on the function of antibodies, like pharmacodynamics, antibody-d...

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Detalles Bibliográficos
Autores principales: Luo, Cheng, Chen, Song, Xu, Na, Wang, Chi, Sai, Wen bo, Zhao, Wei, Li, Ying chun, Hu, Xiao jing, Tian, Hong, Gao, Xiang dong, Yao, Wen bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387714/
https://www.ncbi.nlm.nih.gov/pubmed/28397880
http://dx.doi.org/10.1038/srep46347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387714/
https://www.ncbi.nlm.nih.gov/pubmed/28397880
http://dx.doi.org/10.1038/srep46347

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