Correlated Mutation in the Evolution of Catalysis in Uracil DNA Glycosylase Superfamily

Enzymes in Uracil DNA glycosylase (UDG) superfamily are essential for the removal of uracil. Family 4 UDGa is a robust uracil DNA glycosylase that only acts on double-stranded and single-stranded uracil-containing DNA. Based on mutational, kinetic and modeling analyses, a catalytic mechanism involvi...

Descripción completa

Detalles Bibliográficos
Autores principales: Xia, Bo, Liu, Yinling, Guevara, Jose, Li, Jing, Jilich, Celeste, Yang, Ye, Wang, Liangjiang, Dominy, Brian N., Cao, Weiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387724/
https://www.ncbi.nlm.nih.gov/pubmed/28397787
http://dx.doi.org/10.1038/srep45978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387724/
https://www.ncbi.nlm.nih.gov/pubmed/28397787
http://dx.doi.org/10.1038/srep45978

Ejemplares similares