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Correlated Mutation in the Evolution of Catalysis in Uracil DNA Glycosylase Superfamily

Enzymes in Uracil DNA glycosylase (UDG) superfamily are essential for the removal of uracil. Family 4 UDGa is a robust uracil DNA glycosylase that only acts on double-stranded and single-stranded uracil-containing DNA. Based on mutational, kinetic and modeling analyses, a catalytic mechanism involvi...

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Detalles Bibliográficos
Autores principales:	Xia, Bo, Liu, Yinling, Guevara, Jose, Li, Jing, Jilich, Celeste, Yang, Ye, Wang, Liangjiang, Dominy, Brian N., Cao, Weiguo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387724/ https://www.ncbi.nlm.nih.gov/pubmed/28397787 http://dx.doi.org/10.1038/srep45978

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