Cargando…

Feasibility of melatonin for prevention of delirium in critically ill patients: a protocol for a multicentre, randomised, placebo-controlled study

INTRODUCTION: Delirium is highly prevalent in the intensive care unit (ICU) and is associated with adverse clinical outcomes. At this time, there is no drug that effectively prevents delirium in critically ill patients. Alterations in melatonin secretion and metabolism may contribute to the developm...

Descripción completa

Detalles Bibliográficos
Autores principales:	Burry, Lisa, Scales, Damon, Williamson, David, Foster, Jennifer, Mehta, Sangeeta, Guenette, Melanie, Fan, Eddy, Detsky, Michael, Azad, Azar, Bernard, Francis, Rose, Louise
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2017
Materias:	Intensive Care
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387939/ https://www.ncbi.nlm.nih.gov/pubmed/28363933 http://dx.doi.org/10.1136/bmjopen-2016-015420

Ejemplares similares

Dexmedetomidine after Cardiac Surgery for Prevention of Delirium (EXACTUM) trial protocol: a multicentre randomised, double-blind, placebo-controlled trial
por: Gargadennec, Thomas, et al.
Publicado: (2022)

Study protocol for a prospective randomised double-blind placebo-controlled clinical trial investigating a Better Outcome with Melatonin compared to Placebo Administered to normalize sleep–wake cycle and treat hypoactive ICU Delirium: the Basel BOMP-AID study
por: Hollinger, Alexa, et al.
Publicado: (2020)

Sedation strategy and ICU delirium: a multicentre, population-based propensity score-matched cohort study
por: Casault, Colin, et al.
Publicado: (2021)

PupillOmetry for preDIction of DeliriUM in ICU (PODIUM): protocol for a prospective multicentre cohort study
por: Jaquet, Pierre, et al.
Publicado: (2023)

Prognostication in critically ill patients with severe traumatic brain injury: the TBI-Prognosis multicentre feasibility study
por: Turgeon, Alexis F, et al.
Publicado: (2017)

Melatonin treatment in the prevention of postoperative delirium in cardiac surgery patients
por: Artemiou, Panagiotis, et al.
Publicado: (2015)

Validation of a delirium predictive model in patients admitted to surgical intensive care units: a multicentre prospective observational cohort study
por: Chaiwat, Onuma, et al.
Publicado: (2022)

Dexmedetomidine for the prevention of postoperative delirium in patients after intracranial operation for brain tumours (DEPOD study): a study protocol and statistical plan for a multicentre randomised controlled trial
por: He, Xuan, et al.
Publicado: (2020)

Inhaled amikacin versus placebo to prevent ventilator-associated pneumonia: the AMIKINHAL double-blind multicentre randomised controlled trial protocol
por: Tavernier, Elsa, et al.
Publicado: (2021)

Haemoglobin transfusion threshold in traumatic brain injury optimisation (HEMOTION): a multicentre, randomised, clinical trial protocol
por: Turgeon, Alexis F, et al.
Publicado: (2022)

Evaluating probiotics for the prevention of ventilator-associated pneumonia: a randomised placebo-controlled multicentre trial protocol and statistical analysis plan for PROSPECT
por: Johnstone, Jennie, et al.
Publicado: (2019)

Ascorbic Acid, Corticosteroids and Thiamine in Sepsis (ACTS) protocol and statistical analysis plan: a prospective, multicentre, double-blind, randomised, placebo-controlled clinical trial
por: Moskowitz, Ari, et al.
Publicado: (2019)

Mobilisation in the EveNing to TreAt deLirium (MENTAL): protocol for a mixed-methods feasibility randomised controlled trial
por: McWilliams, David, et al.
Publicado: (2023)

Efficacy of halopeRIdol to decrease the burden of Delirium In adult Critically ill patiEnts (EuRIDICE): study protocol for a prospective randomised multi-centre double-blind placebo-controlled clinical trial in the Netherlands
por: Smit, Lisa, et al.
Publicado: (2020)

Neurologic Physiology after Removal of Therapy (NeuPaRT) study: study protocol of a multicentre, prospective, observational, pilot feasibility study of neurophysiology after withdrawal of life-sustaining measures
por: Gofton, Teneille, et al.
Publicado: (2023)

Biomarker-guided implementation of the KDIGO guidelines to reduce the occurrence of acute kidney injury in patients after cardiac surgery (PrevAKI-multicentre): protocol for a multicentre, observational study followed by randomised controlled feasibility trial
por: Küllmar, Mira, et al.
Publicado: (2020)

Cholinesterase alterations in delirium after cardiosurgery: a German monocentric prospective study
por: Adam, Elisabeth Hannah, et al.
Publicado: (2020)

Rapid rEcognition of COrticosteRoiD resistant or sensitive Sepsis (RECORDS): study protocol for a multicentre, placebo-controlled, biomarker-guided, adaptive Bayesian design basket trial
por: Fleuriet, Jérôme, et al.
Publicado: (2023)

Study protocol for the safety and efficacy of probiotic therapy on days alive and out of hospital in adult ICU patients: the multicentre, randomised, placebo-controlled Restoration Of gut microflora in Critical Illness Trial (ROCIT)
por: Litton, Edward, et al.
Publicado: (2020)

Delirium and neuropsychological outcomes in critically Ill patients with COVID-19: a cohort study
por: Ragheb, Jacqueline, et al.
Publicado: (2021)

Prevention of early ventilation-acquired pneumonia (VAP) in comatose brain-injured patients by a single dose of ceftriaxone: PROPHY-VAP study protocol, a multicentre, randomised, double-blind, placebo-controlled trial
por: Dahyot-Fizelier, Claire, et al.
Publicado: (2018)

Melatonin and melatonin agonists to prevent and treat delirium in critical illness: a systematic review protocol
por: Foster, Jennifer, et al.
Publicado: (2016)

Effect of sedation with inhaled anaesthetics on cognitive and psychiatric outcomes in critically ill adults: a systematic review protocol
por: Cuninghame, Sean, et al.
Publicado: (2022)

Multicentre observational status-epilepticus registry: protocol for ICTAL
por: Jacq, Gwenaelle, et al.
Publicado: (2022)

Pharmacological interventions for prevention and management of delirium in intensive care patients: a systematic overview of reviews and meta-analyses
por: Barbateskovic, Marija, et al.
Publicado: (2019)

A double-blind, placebo-controlled, randomised, multicentre, proof-of-concept and dose-finding phase II clinical trial to investigate the safety, tolerability and efficacy of adrecizumab in patients with septic shock and elevated adrenomedullin concentration (AdrenOSS-2)
por: Geven, Christopher, et al.
Publicado: (2019)

How do doctors and nurses manage delirium in intensive care units? A qualitative study using focus groups
por: Palacios-Ceña, Domingo, et al.
Publicado: (2016)

Critical Care Cycling to Improve Lower Extremity Strength (CYCLE): protocol for an international, multicentre randomised clinical trial of early in-bed cycling for mechanically ventilated patients
por: Kho, Michelle E, et al.
Publicado: (2023)

Relaxation for Critically ill Patient Outcomes and Stress-coping Enhancement (REPOSE): a protocol for a pilot randomised trial of an integrative intervention to improve critically ill patients’ delirium and related outcomes
por: Papathanassoglou, Elizabeth D E, et al.
Publicado: (2019)

Effect of high-dose vitamin D3 on 28-day mortality in adult critically ill patients with severe vitamin D deficiency: a study protocol of a multicentre, placebo-controlled double-blind phase III RCT (the VITDALIZE study)
por: Amrein, Karin, et al.
Publicado: (2019)

Qualitative descriptive study to explore nurses’ perceptions and experience on pain, agitation and delirium management in a community intensive care unit
por: Tsang, Jennifer L Y, et al.
Publicado: (2019)

Development and validation of a postoperative delirium prediction model for patients admitted to an intensive care unit in China: a prospective study
por: Xing, Huanmin, et al.
Publicado: (2019)

Family satisfaction with critical care in the UK: a multicentre cohort study
por: Ferrando, Paloma, et al.
Publicado: (2019)

Comparison of propofol and dexmedetomidine infused overnight to treat hyperactive and mixed ICU delirium: a protocol for the Basel ProDex clinical trial
por: Hollinger, Alexa, et al.
Publicado: (2017)

Knowledge, attitudes and practices of ICU nurses regarding subsyndromal delirium among 20 hospitals in China: a descriptive cross-sectional survey
por: Xing, Huanmin, et al.
Publicado: (2022)

Protocolised reduction of non-resuscitation fluids versus usual care in patients with septic shock (REDUSE): a protocol for a multicentre feasibility trial
por: Lindén, Anja, et al.
Publicado: (2023)

Study protocol for a multicentre randomised controlled trial: Safety, Tolerability, efficacy and quality of life Of a human recombinant alkaline Phosphatase in patients with sepsis-associated Acute Kidney Injury (STOP-AKI)
por: Peters, Esther, et al.
Publicado: (2016)

Design and rationale of the COVID-19 Critical Care Consortium international, multicentre, observational study
por: Li Bassi, Gianluigi, et al.
Publicado: (2020)

Multicentre observational study on practice of ventilation in brain injured patients: the VENTIBRAIN study protocol
por: Robba, Chiara, et al.
Publicado: (2021)

Regional citrate versus systemic heparin anticoagulation for continuous renal replacement therapy in critically ill patients with acute kidney injury (RICH) trial: study protocol for a multicentre, randomised controlled trial
por: Meersch, Melanie, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_dfame8eroraej9k7doqahmn9d6