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In silico design of the first DNA-independent mechanism-based inhibitor of mammalian DNA methyltransferase Dnmt1
BACKGROUND: We use our earlier experimental studies of the catalytic mechanism of DNA methyltransferases to prepare in silico a family of novel mechanism-based inhibitors of human Dnmt1. Highly specific inhibitors of DNA methylation can be used for analysis of human epigenome and for the creation of...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388339/ https://www.ncbi.nlm.nih.gov/pubmed/28399172 http://dx.doi.org/10.1371/journal.pone.0174410 |