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In silico design of the first DNA-independent mechanism-based inhibitor of mammalian DNA methyltransferase Dnmt1

BACKGROUND: We use our earlier experimental studies of the catalytic mechanism of DNA methyltransferases to prepare in silico a family of novel mechanism-based inhibitors of human Dnmt1. Highly specific inhibitors of DNA methylation can be used for analysis of human epigenome and for the creation of...

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Detalles Bibliográficos
Autores principales:	Miletić, Vedran, Odorčić, Ivica, Nikolić, Patrik, Svedružić, Željko M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388339/ https://www.ncbi.nlm.nih.gov/pubmed/28399172 http://dx.doi.org/10.1371/journal.pone.0174410

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