Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations

In yeast, dNTP pools expand drastically during DNA damage response. We show that similar dNTP elevation occurs in strains, in which intrinsic replisome defects promote the participation of error-prone DNA polymerase ζ (Polζ) in replication of undamaged DNA. To understand the significance of dNTP poo...

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Detalles Bibliográficos
Autores principales: Kochenova, Olga V., Bezalel-Buch, Rachel, Tran, Phong, Makarova, Alena V., Chabes, Andrei, Burgers, Peter M. J., Shcherbakova, Polina V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388397/
https://www.ncbi.nlm.nih.gov/pubmed/28180291
http://dx.doi.org/10.1093/nar/gkw1149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388397/
https://www.ncbi.nlm.nih.gov/pubmed/28180291
http://dx.doi.org/10.1093/nar/gkw1149

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