Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells

Genome lesions trigger biological responses that help cells manage damaged DNA, improving cell survival. Pol eta is a translesion synthesis (TLS) polymerase that bypasses lesions that block replicative polymerases, avoiding continued stalling of replication forks, which could lead to cell death. p53...

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Detalles Bibliográficos
Autores principales: Lerner, Leticia K., Francisco, Guilherme, Soltys, Daniela T., Rocha, Clarissa R.R., Quinet, Annabel, Vessoni, Alexandre T., Castro, Ligia P., David, Taynah I.P., Bustos, Silvina O., Strauss, Bryan E., Gottifredi, Vanesa, Stary, Anne, Sarasin, Alain, Chammas, Roger, Menck, Carlos F.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388406/
https://www.ncbi.nlm.nih.gov/pubmed/28180309
http://dx.doi.org/10.1093/nar/gkw1196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388406/
https://www.ncbi.nlm.nih.gov/pubmed/28180309
http://dx.doi.org/10.1093/nar/gkw1196

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