Challenges of CRISPR/Cas9 applications for long non-coding RNA genes

The CRISPR/Cas9 system provides a revolutionary genome editing tool for all areas of molecular biology. In long non-coding RNA (lncRNA) research, the Cas9 nuclease can delete lncRNA genes or introduce RNA-destabilizing elements into their locus. The nuclease-deficient dCas9 mutant retains its RNA-de...

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Detalles Bibliográficos
Autores principales: Goyal, Ashish, Myacheva, Ksenia, Groß, Matthias, Klingenberg, Marcel, Duran Arqué, Berta, Diederichs, Sven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388423/
https://www.ncbi.nlm.nih.gov/pubmed/28180319
http://dx.doi.org/10.1093/nar/gkw883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388423/
https://www.ncbi.nlm.nih.gov/pubmed/28180319
http://dx.doi.org/10.1093/nar/gkw883

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