Misincorporation by RNA polymerase is a major source of transcription pausing in vivo

The transcription error rate estimated from mistakes in end product RNAs is 10(−3)–10(−5). We analyzed the fidelity of nascent RNAs from all actively transcribing elongation complexes (ECs) in Escherichia coli and Saccharomyces cerevisiae and found that 1–3% of all ECs in wild-type cells, and 5–7% o...

Descripción completa

Detalles Bibliográficos
Autores principales: James, Katherine, Gamba, Pamela, Cockell, Simon J., Zenkin, Nikolay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388426/
https://www.ncbi.nlm.nih.gov/pubmed/28180286
http://dx.doi.org/10.1093/nar/gkw969

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388426/
https://www.ncbi.nlm.nih.gov/pubmed/28180286
http://dx.doi.org/10.1093/nar/gkw969

Ejemplares similares