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Misincorporation by RNA polymerase is a major source of transcription pausing in vivo
The transcription error rate estimated from mistakes in end product RNAs is 10(−3)–10(−5). We analyzed the fidelity of nascent RNAs from all actively transcribing elongation complexes (ECs) in Escherichia coli and Saccharomyces cerevisiae and found that 1–3% of all ECs in wild-type cells, and 5–7% o...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388426/ https://www.ncbi.nlm.nih.gov/pubmed/28180286 http://dx.doi.org/10.1093/nar/gkw969 |