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Effects of the RGD loop and C-terminus of rhodostomin on regulating integrin αIIbβ3 recognition
Rhodostomin (Rho) is a medium disintegrin containing a (48)PRGDMP motif. We here showed that Rho proteins with P48A, M52W, and P53N mutations can selectively inhibit integrin αIIbβ3. To study the roles of the RGD loop and C-terminal region in disintegrins, we expressed Rho (48)PRGDMP and (48)ARGDWN...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388508/ https://www.ncbi.nlm.nih.gov/pubmed/28399159 http://dx.doi.org/10.1371/journal.pone.0175321 |