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Effects of the RGD loop and C-terminus of rhodostomin on regulating integrin αIIbβ3 recognition

Rhodostomin (Rho) is a medium disintegrin containing a (48)PRGDMP motif. We here showed that Rho proteins with P48A, M52W, and P53N mutations can selectively inhibit integrin αIIbβ3. To study the roles of the RGD loop and C-terminal region in disintegrins, we expressed Rho (48)PRGDMP and (48)ARGDWN...

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Detalles Bibliográficos
Autores principales:	Chang, Yao-Tsung, Shiu, Jia-Hau, Huang, Chun-Hao, Chen, Yi-Chun, Chen, Chiu-Yueh, Chang, Yung-Sheng, Chuang, Woei-Jer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388508/ https://www.ncbi.nlm.nih.gov/pubmed/28399159 http://dx.doi.org/10.1371/journal.pone.0175321

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