Hexokinase II–derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells

Overexpression of mitochondria-bound hexokinase II (HKII) in cancer cells plays an important role in their metabolic reprogramming and protects them against apoptosis, thereby facilitating their growth and proliferation. Here, we show that covalently coupling a peptide corresponding to the mitochond...

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Detalles Bibliográficos
Autores principales: Woldetsadik, Abiy D., Vogel, Maria C., Rabeh, Wael M., Magzoub, Mazin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388548/
https://www.ncbi.nlm.nih.gov/pubmed/28183803
http://dx.doi.org/10.1096/fj.201601173R

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388548/
https://www.ncbi.nlm.nih.gov/pubmed/28183803
http://dx.doi.org/10.1096/fj.201601173R

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