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Hexokinase II–derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells
Overexpression of mitochondria-bound hexokinase II (HKII) in cancer cells plays an important role in their metabolic reprogramming and protects them against apoptosis, thereby facilitating their growth and proliferation. Here, we show that covalently coupling a peptide corresponding to the mitochond...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Federation of American Societies for Experimental Biology
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388548/ https://www.ncbi.nlm.nih.gov/pubmed/28183803 http://dx.doi.org/10.1096/fj.201601173R |