Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions

Base editing is a recently developed approach to genome editing that uses a fusion protein containing a catalytically defective Streptococcus pyogenes Cas9, a cytidine deaminase, and an inhibitor of base excision repair to induce programmable, single-nucleotide changes in the DNA of living cells wit...

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Detalles Bibliográficos
Autores principales: Kim, Y. Bill, Komor, Alexis C., Levy, Jonathan M., Packer, Michael S., Zhao, Kevin T., Liu, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388574/
https://www.ncbi.nlm.nih.gov/pubmed/28191901
http://dx.doi.org/10.1038/nbt.3803

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388574/
https://www.ncbi.nlm.nih.gov/pubmed/28191901
http://dx.doi.org/10.1038/nbt.3803

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