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Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions
Base editing is a recently developed approach to genome editing that uses a fusion protein containing a catalytically defective Streptococcus pyogenes Cas9, a cytidine deaminase, and an inhibitor of base excision repair to induce programmable, single-nucleotide changes in the DNA of living cells wit...
Autores principales: | Kim, Y. Bill, Komor, Alexis C., Levy, Jonathan M., Packer, Michael S., Zhao, Kevin T., Liu, David R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388574/ https://www.ncbi.nlm.nih.gov/pubmed/28191901 http://dx.doi.org/10.1038/nbt.3803 |
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