Cargando…
Control of gdhR Expression in Neisseria gonorrhoeae via Autoregulation and a Master Repressor (MtrR) of a Drug Efflux Pump Operon
The MtrCDE efflux pump of Neisseria gonorrhoeae contributes to gonococcal resistance to a number of antibiotics used previously or currently in treatment of gonorrhea, as well as to host-derived antimicrobials that participate in innate defense. Overexpression of the MtrCDE efflux pump increases gon...
Autores principales: | Rouquette-Loughlin, Corinne E., Zalucki, Yaramah M., Dhulipala, Vijaya L., Balthazar, Jacqueline T., Doyle, Raúl G., Nicholas, Robert A., Begum, Afrin A., Raterman, Erica L., Jerse, Ann E., Shafer, William M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388806/ https://www.ncbi.nlm.nih.gov/pubmed/28400529 http://dx.doi.org/10.1128/mBio.00449-17 |
Ejemplares similares
-
Dueling Regulatory Properties of a Transcriptional Activator (MtrA) and Repressor (MtrR) That Control Efflux Pump Gene Expression in Neisseria gonorrhoeae
por: Zalucki, Yaramah M., et al.
Publicado: (2012) -
Gonococcal Clinical Strains Bearing a Common gdhR Single Nucleotide Polymorphism That Results in Enhanced Expression of the Virulence Gene lctP Frequently Possess a mtrR Promoter Mutation That Decreases Antibiotic Susceptibility
por: Ayala, Julio C., et al.
Publicado: (2022) -
Structural, Biochemical, and In Vivo Characterization of MtrR-Mediated Resistance to Innate Antimicrobials by the Human Pathogen Neisseria gonorrhoeae
por: Beggs, Grace A., et al.
Publicado: (2019) -
The Transcriptional Repressor, MtrR, of the mtrCDE Efflux Pump Operon of Neisseria gonorrhoeae Can Also Serve as an Activator of “off Target” Gene (glnE) Expression
por: Johnson, Paul J. T., et al.
Publicado: (2015) -
MtrR Control of a Transcriptional Regulatory Pathway in Neisseria meningitidis That Influences Expression of a Gene (nadA) Encoding a Vaccine Candidate
por: Cloward, Jason M., et al.
Publicado: (2013)