Acrolein acts as a neurotoxin in the nigrostriatal dopaminergic system of rat: involvement of α-synuclein aggregation and programmed cell death

Clinical studies report significant increases in acrolein (an α,β-unsaturated aldehyde) in the substantia nigra (SN) of patients with Parkinson’s disease (PD). In the present study, acrolein-induced neurotoxicity in the nigrostriatal dopaminergic system was investigated by local infusion of acrolein...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yi-Ting, Lin, Hui-Ching, Zhao, Wei-Zhong, Huang, Hui-Ju, Lo, Yu-Li, Wang, Hsiang-Tsui, Maan-Yuh Lin, Anya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388849/
https://www.ncbi.nlm.nih.gov/pubmed/28401906
http://dx.doi.org/10.1038/srep45741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388849/
https://www.ncbi.nlm.nih.gov/pubmed/28401906
http://dx.doi.org/10.1038/srep45741

Ejemplares similares