Cargando…

Acrolein acts as a neurotoxin in the nigrostriatal dopaminergic system of rat: involvement of α-synuclein aggregation and programmed cell death

Clinical studies report significant increases in acrolein (an α,β-unsaturated aldehyde) in the substantia nigra (SN) of patients with Parkinson’s disease (PD). In the present study, acrolein-induced neurotoxicity in the nigrostriatal dopaminergic system was investigated by local infusion of acrolein...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yi-Ting, Lin, Hui-Ching, Zhao, Wei-Zhong, Huang, Hui-Ju, Lo, Yu-Li, Wang, Hsiang-Tsui, Maan-Yuh Lin, Anya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388849/ https://www.ncbi.nlm.nih.gov/pubmed/28401906 http://dx.doi.org/10.1038/srep45741

Ejemplares similares

Neuroprotective effect of selumetinib on acrolein-induced neurotoxicity
por: Huang, Hui-Ju, et al.
Publicado: (2021)

Acrolein induces mtDNA damages, mitochondrial fission and mitophagy in human lung cells
por: Wang, Hsiang-Tsui, et al.
Publicado: (2017)

Roles of Autophagy in MPP(+)-Induced Neurotoxicity In Vivo: The Involvement of Mitochondria and α-Synuclein Aggregation
por: Hung, Kai-Chih, et al.
Publicado: (2014)

No apparent transmission of transgenic α–synuclein into nigrostriatal dopaminergic neurons in multiple mouse models
por: Sastry, Namratha, et al.
Publicado: (2015)

Impact of α‐synuclein spreading on the nigrostriatal dopaminergic pathway depends on the onset of the pathology
por: Sun, Fanfan, et al.
Publicado: (2021)

Endogenous dynorphin protects against neurotoxin-elicited nigrostriatal dopaminergic neuron damage and motor deficits in mice
por: Wang, Qingshan, et al.
Publicado: (2012)

Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression
por: Wang, Yong, et al.
Publicado: (2020)

Effects of LRRK2 Inhibitors on Nigrostriatal Dopaminergic Neurotransmission
por: Qin, Qi, et al.
Publicado: (2016)

Naringin: A Protector of the Nigrostriatal Dopaminergic Projection
por: Jung, Un Ju, et al.
Publicado: (2014)

Nigrostriatal dopaminergic depletion increases static orofacial allodynia
por: Dieb, Wisam, et al.
Publicado: (2016)

Microglial depletion does not impact alpha-synuclein aggregation or nigrostriatal degeneration in the rat preformed fibril model
por: Stoll, Anna C., et al.
Publicado: (2023)

High Dietary Iron Supplement Induces the Nigrostriatal Dopaminergic Neurons Lesion in Transgenic Mice Expressing Mutant A53T Human Alpha-Synuclein
por: Jia, Fengju, et al.
Publicado: (2018)

Acrolein preferentially damages nucleolus eliciting ribosomal stress and apoptosis in human cancer cells
por: Wang, Hsiang-tsui, et al.
Publicado: (2016)

Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration
por: Mor, Danielle E., et al.
Publicado: (2017)

A Current Review of Cypermethrin-Induced Neurotoxicity and Nigrostriatal Dopaminergic Neurodegeneration
por: Singh, Anand Kumar, et al.
Publicado: (2012)

Dopa-responsive dystonia: a syndrome of selective nigrostriatal dopaminergic deficiency.
por: Jeon, B. S.
Publicado: (1997)

Lesion of the dopaminergic nigrostriatal pathway induces trigeminal dynamic mechanical allodynia
por: Dieb, Wisam, et al.
Publicado: (2014)

Clinical Features Indicating Nigrostriatal Dopaminergic Degeneration in Drug-Induced Parkinsonism
por: Lee, Seung Ha, et al.
Publicado: (2017)

Unilateral intranigral administration of β-sitosterol β-D-glucoside triggers pathological α-synuclein spreading and bilateral nigrostriatal dopaminergic neurodegeneration in the rat
por: Soto-Rojas, Luis O., et al.
Publicado: (2020)

Nigrostriatal neuronal death following chronic dichlorvos exposure: crosstalk between mitochondrial impairments, α synuclein aggregation, oxidative damage and behavioral changes
por: BK, Binukumar, et al.
Publicado: (2010)

Atrazine Causes Autophagy- and Apoptosis-Related Neurodegenerative Effects in Dopaminergic Neurons in the Rat Nigrostriatal Dopaminergic System
por: Song, Xiao-Yao, et al.
Publicado: (2015)

Nigrostriatal dynein changes in A53T alpha-synuclein transgenic mice
por: Liu, Yan, et al.
Publicado: (2014)

Identification of acrolein metabolites in human buccal cells, blood, and urine after consumption of commercial fried food
por: Wang, Tse‐Wen, et al.
Publicado: (2019)

Urinary Dysfunction Is Associated with Nigrostriatal Dopaminergic Degeneration in Early and Untreated Patients with Parkinson's Disease
por: Wang, Jing, et al.
Publicado: (2020)

Enhancing Anticancer Effect of Gefitinib across the Blood–Brain Barrier Model Using Liposomes Modified with One α-Helical Cell-Penetrating Peptide or Glutathione and Tween 80
por: Lin, Kuan-Hung, et al.
Publicado: (2016)

Pyruvate kinase M2 modification by a lipid peroxidation byproduct acrolein contributes to kidney fibrosis
por: Kuo, Chin-Wei, et al.
Publicado: (2023)

In vivo Assessment of the Human Nigrostriatal Dopaminergic System Using Positron Emission Tomography
por: Leenders, K. L.
Publicado: (1992)

Long-term hyperglycemia aggravates α-synuclein aggregation and dopaminergic neuronal loss in a Parkinson’s disease mouse model
por: Lv, Yi-Qing, et al.
Publicado: (2022)

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression
por: Bourdenx, Mathieu, et al.
Publicado: (2015)

α-Synuclein-Dependent Calcium Entry Underlies Differential Sensitivity of Cultured SN and VTA Dopaminergic Neurons to a Parkinsonian Neurotoxin
por: Lieberman, Ori J., et al.
Publicado: (2017)

Acrolein
por: Gómes, R.
Publicado: (2002)

Acrolein contributes to human colorectal tumorigenesis through the activation of RAS-MAPK pathway
por: Tsai, Hong-Chieh, et al.
Publicado: (2021)

Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit
por: Pham, Anh H., et al.
Publicado: (2012)

Beneficial effect of estrogen on nigrostriatal dopaminergic neurons in drug-naïve postmenopausal Parkinson’s disease
por: Lee, Yang Hyun, et al.
Publicado: (2019)

Alteration of colonic excitatory tachykininergic motility and enteric inflammation following dopaminergic nigrostriatal neurodegeneration
por: Pellegrini, Carolina, et al.
Publicado: (2016)

Astrocytes and retrograde degeneration of nigrostriatal dopaminergic neurons in Parkinson’s disease: removing axonal debris
por: Morales, Ingrid, et al.
Publicado: (2021)

A Mouse Model of Nigrostriatal Dopaminergic Axonal Degeneration As a Tool for Testing Neuroprotectors
por: Kolacheva, A. A., et al.
Publicado: (2021)

Urinary acrolein protein conjugates-to-creatinine ratio is positively associated with diabetic peripheral neuropathy in patients with type 2 diabetes mellitus
por: Wu, Tsung-Hui, et al.
Publicado: (2023)

Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons
por: Taschenberger, Grit, et al.
Publicado: (2011)

Dopamine-dependent early synaptic and motor dysfunctions induced by α-synuclein in the nigrostriatal circuit
por: Tozzi, Alessandro, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_o29ahrj50rh9ntd7j7d60oj0rf