Overexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis

Heparanase is an endo-glucuronidase that degrades heparan sulfate chains. The enzyme is expressed at a low level in normal organs; however, elevated expression of heparanase has been detected in several inflammatory conditions, e.g. in the synovial joints of rheumatoid arthritis (RA) patients. Herei...

Descripción completa

Detalles Bibliográficos
Autores principales: Digre, Andreas, Singh, Kailash, Åbrink, Magnus, Reijmers, Rogier M., Sandler, Stellan, Vlodavsky, Israel, Li, Jin-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388921/
https://www.ncbi.nlm.nih.gov/pubmed/28401953
http://dx.doi.org/10.1038/srep46229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388921/
https://www.ncbi.nlm.nih.gov/pubmed/28401953
http://dx.doi.org/10.1038/srep46229

Ejemplares similares