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Is Huntingtin Dispensable in the Adult Brain?

Huntingtin (HTT) is an essential protein during early embryogenesis and the development of the central nervous system (CNS). Conditional knock-out of mouse Huntingtin (Htt) expression in the CNS beginning during neural development, as well as reducing Htt expression only during embryonic and early p...

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Detalles Bibliográficos
Autores principales: Liu, Jeh-Ping, Zeitlin, Scott O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389021/
https://www.ncbi.nlm.nih.gov/pubmed/28339401
http://dx.doi.org/10.3233/JHD-170235