Generation and Characterization of Knock-in Mouse Models Expressing Versions of Huntingtin with Either an N17 or a Combined PolyQ and Proline-Rich Region Deletion

Background: The polyglutamine (polyQ) stretch of the Huntingtin protein (HTT) in mammals is flanked by a highly conserved 17 amino acid N-terminal domain (N17), and a proline-rich region (PRR). The PRR is a binding site for many HTT-interacting proteins, and the N17 domain regulates several normal H...

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Detalles Bibliográficos
Autores principales: André, Emily A., Braatz, Elise M., Liu, Jeh-Ping, Zeitlin, Scott O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389044/
https://www.ncbi.nlm.nih.gov/pubmed/28211815
http://dx.doi.org/10.3233/JHD-160231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389044/
https://www.ncbi.nlm.nih.gov/pubmed/28211815
http://dx.doi.org/10.3233/JHD-160231

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