Palmitate Increases β-site AβPP-Cleavage Enzyme 1 Activity and Amyloid-β Genesis by Evoking Endoplasmic Reticulum Stress and Subsequent C/EBP Homologous Protein Activation

Epidemiological studies implicate diets rich in saturated free fatty acids (sFFA) as a potential risk factor for developing Alzheimer’s disease (AD). In particular, high plasma levels of the sFFA palmitic acid (palmitate) were shown to inversely correlate with cognitive function. However, the cellul...

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Detalles Bibliográficos
Autores principales: Marwarha, Gurdeep, Rostad, Stephen, Lilek, Jaclyn, Kleinjan, Mason, Schommer, Jared, Ghribi, Othman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389045/
https://www.ncbi.nlm.nih.gov/pubmed/28304295
http://dx.doi.org/10.3233/JAD-161130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389045/
https://www.ncbi.nlm.nih.gov/pubmed/28304295
http://dx.doi.org/10.3233/JAD-161130

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