Overlapping roles for PARP1 and PARP2 in the recruitment of endogenous XRCC1 and PNKP into oxidized chromatin

A critical step of DNA single-strand break repair is the rapid recruitment of the scaffold protein XRCC1 that interacts with, stabilizes and stimulates multiple enzymatic components of the repair process. XRCC1 recruitment is promoted by PARP1, an enzyme that is activated following DNA damage and sy...

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Detalles Bibliográficos
Autores principales: Hanzlikova, Hana, Gittens, William, Krejcikova, Katerina, Zeng, Zhihong, Caldecott, Keith W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389470/
https://www.ncbi.nlm.nih.gov/pubmed/27965414
http://dx.doi.org/10.1093/nar/gkw1246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389470/
https://www.ncbi.nlm.nih.gov/pubmed/27965414
http://dx.doi.org/10.1093/nar/gkw1246

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