Harnessing human ADAR2 for RNA repair – Recoding a PINK1 mutation rescues mitophagy

Site-directed A-to-I RNA editing is a technology for re-programming genetic information at the RNA-level. We describe here the first design of genetically encodable guideRNAs that enable the re-addressing of human ADAR2 toward specific sites in user-defined mRNA targets. Up to 65% editing yield has...

Descripción completa

Detalles Bibliográficos
Autores principales: Wettengel, Jacqueline, Reautschnig, Philipp, Geisler, Sven, Kahle, Philipp J., Stafforst, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389476/
https://www.ncbi.nlm.nih.gov/pubmed/27907896
http://dx.doi.org/10.1093/nar/gkw911

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389476/
https://www.ncbi.nlm.nih.gov/pubmed/27907896
http://dx.doi.org/10.1093/nar/gkw911

Ejemplares similares