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Harnessing human ADAR2 for RNA repair – Recoding a PINK1 mutation rescues mitophagy
Site-directed A-to-I RNA editing is a technology for re-programming genetic information at the RNA-level. We describe here the first design of genetically encodable guideRNAs that enable the re-addressing of human ADAR2 toward specific sites in user-defined mRNA targets. Up to 65% editing yield has...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389476/ https://www.ncbi.nlm.nih.gov/pubmed/27907896 http://dx.doi.org/10.1093/nar/gkw911 |