Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity

Ribonucleotides (rNs) incorporated in the genome by DNA polymerases (Pols) are removed by RNase H2. Cytidine and guanosine preferentially accumulate over the other rNs. Here we show that human Pol η can incorporate cytidine monophosphate (rCMP) opposite guanine, 8-oxo-7,8-dihydroguanine, 8-methyl-2΄...

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Detalles Bibliográficos
Autores principales: Mentegari, Elisa, Crespan, Emmanuele, Bavagnoli, Laura, Kissova, Miroslava, Bertoletti, Federica, Sabbioneda, Simone, Imhof, Ralph, Sturla, Shana J., Nilforoushan, Arman, Hübscher, Ulrich, van Loon, Barbara, Maga, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389505/
https://www.ncbi.nlm.nih.gov/pubmed/27994034
http://dx.doi.org/10.1093/nar/gkw1275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389505/
https://www.ncbi.nlm.nih.gov/pubmed/27994034
http://dx.doi.org/10.1093/nar/gkw1275

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