Genetic selection for mistranslation rescues a defective co-chaperone in yeast

Despite the general requirement for translation fidelity, mistranslation can be an adaptive response. We selected spontaneous second site mutations that suppress the stress sensitivity caused by a Saccharomyces cerevisiae tti2 allele with a Leu to Pro mutation at residue 187, identifying a single nu...

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Detalles Bibliográficos
Autores principales: Hoffman, Kyle S., Berg, Matthew D., Shilton, Brian H., Brandl, Christopher J., O'Donoghue, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389508/
https://www.ncbi.nlm.nih.gov/pubmed/27899648
http://dx.doi.org/10.1093/nar/gkw1021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389508/
https://www.ncbi.nlm.nih.gov/pubmed/27899648
http://dx.doi.org/10.1093/nar/gkw1021

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