Interstrand cross-linking implies contrasting structural consequences for DNA: insights from molecular dynamics

Oxidatively-generated interstrand cross-links rank among the most deleterious DNA lesions. They originate from abasic sites, whose aldehyde group can form a covalent adduct after condensation with the exocyclic amino group of purines, sometimes with remarkably high yields. We use explicit solvent mo...

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Detalles Bibliográficos
Autores principales: Bignon, Emmanuelle, Dršata, Tomáš, Morell, Christophe, Lankaš, Filip, Dumont, Elise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389527/
https://www.ncbi.nlm.nih.gov/pubmed/27986856
http://dx.doi.org/10.1093/nar/gkw1253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389527/
https://www.ncbi.nlm.nih.gov/pubmed/27986856
http://dx.doi.org/10.1093/nar/gkw1253

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