Proximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2

AID deaminates C to U in either strand of Ig genes, exclusively producing C:G/G:C to T:A/A:T transition mutations if U is left unrepaired. Error-prone processing by UNG2 or mismatch repair diversifies mutation, predominantly at C:G or A:T base pairs, respectively. Here, we show that transversions at...

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Detalles Bibliográficos
Autores principales: Thientosapol, Eddy Sanchai, Sharbeen, George, Lau, K.K. Edwin, Bosnjak, Daniel, Durack, Timothy, Stevanovski, Igor, Weninger, Wolfgang, Jolly, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389528/
https://www.ncbi.nlm.nih.gov/pubmed/28039326
http://dx.doi.org/10.1093/nar/gkw1300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389528/
https://www.ncbi.nlm.nih.gov/pubmed/28039326
http://dx.doi.org/10.1093/nar/gkw1300

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