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SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription
SIRT7 is an NAD(+)-dependent protein deacetylase that regulates cell growth and proliferation. Previous studies have shown that SIRT7 is required for RNA polymerase I (Pol I) transcription and pre-rRNA processing. Here, we took a proteomic approach to identify novel molecular targets and characteriz...
Autores principales: | Blank, Maximilian F., Chen, Sifan, Poetz, Fabian, Schnölzer, Martina, Voit, Renate, Grummt, Ingrid |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389538/ https://www.ncbi.nlm.nih.gov/pubmed/28426094 http://dx.doi.org/10.1093/nar/gkx053 |
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